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Avoid use of fentanyl transdermal system in the patient who would require the concomitant administration of a monoamine oxidase (MAO) inhibitor, or within 1. MAO inhibitors has been reported with opioid analgesics. Use In Specific Populations Pregnancy: Based on animal data, may cause fetal harm. Nursing Mothers: Breast- feeding is not advised in mothers treated with fentanyl transdermal system. Pediatric Use: Safety and efficacy in pediatric patients below the age of 2 years have not been established. To guard against accidental ingestion by children, use caution when choosing the application site for fentanyl transdermal system. Geriatric Use: Administer fentanyl transdermal system with caution, and in reduced dosages in elderly patients. Hepatic or Renal Impairment: Administer fentanyl transdermal system with caution. Monitor for signs of fentanyl toxicity and reduce dosage, if necessary. 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